While the below settings are being called "Optimal", it needs to be understood what "Optimal" means. These settings will help get every pixel from the server to you TV or screen that is meant to be seen. With that being said, if the server you are on or your own connection isn't substantial enough to receive all the digital bits you may encounter some buffering from time to time. In that case it's best to step your Video quality down to the next Quality profile down.
Mobile apps are treated differently, while up until now most of your apps you use with Plex have been free (Roku, FireTV, Android TV etc). Mobile apps are a one time $5 ACTIVATION fee that is paid directly to Plex from within the app. If you unlock it on an IOS device, then all IOS devices are now ACTIVATED for your account. If you ACTIVATE it while on an Android device, all Android devices will be unlocked for your account.